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KMID : 0352120170320010063
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Journal of Kyung Hee University
2017 Volume.32 No. 1 p.63 ~ p.66
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Meperidine-induced Serotonin Syndrome : A Case Report
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Shin Jun-Oik
Ahn Sang-Eun
Kim Keon-Sik
Kang Hee-Yong
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Abstract
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Serotonin syndrome is a potentially life-threatening drug reaction characterized by mental status change, increased neuromuscular tone, and autonomic insta bility. Meperidine is an opioid analgesic used by postoperative pain control; however, it interacts with some serotonin agonists and may cause serotonin syndrome. A patient who had been taking serotoninnorepinephrine reuptake inhibitor, tricyclic antidepressant and stopped at 1day before surgery experienced muscle rigidity, tremor and mental status change after receiving an infusion of meperidine for postoperative pain control. She improved rapidly after discontinuation of meperidine with supportive care and administration of benzodiazepine.
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KEYWORD
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Serotonin syndrome, Meperidine, Antidepressants, Serotonin-norepinephrine reuptake inhibitor, Tricyclic antidepressant
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